Comments on: Quiz: Hair-on-End Skull http://www.unboundedmedicine.com/2006/10/11/quiz-hair-on-end-skull/ Medicine as it must be: Unlimited Sat, 22 Nov 2008 07:06:17 +0000 http://wordpress.org/?v=2.6.2 By: Grab A Cuppa Grand Rounds! // Emergiblog http://www.unboundedmedicine.com/2006/10/11/quiz-hair-on-end-skull/#comment-9198 Grab A Cuppa Grand Rounds! // Emergiblog Tue, 17 Oct 2006 16:02:43 +0000 http://www.unboundedmedicine.com/2006/10/11/quiz-hair-on-end-skull/#comment-9198 [...] I know we all want “glowing hair” but this is amazing. Last week’s host, Dr. Jon Mikel, presents a “quiz” that stumped me (easily done, by the way). Check out Hair-On-End Skull at Unbounded Medicine. What is that stuff? And Jon takes it up-to-eleven with this post, where a photo is worth a thousand words. A bit of a stunner, check out Limb-to-Crotch! [...] [...] I know we all want “glowing hair” but this is amazing. Last week’s host, Dr. Jon Mikel, presents a “quiz” that stumped me (easily done, by the way). Check out Hair-On-End Skull at Unbounded Medicine. What is that stuff? And Jon takes it up-to-eleven with this post, where a photo is worth a thousand words. A bit of a stunner, check out Limb-to-Crotch! [...]

]]> By: JonMikel, M.D. http://www.unboundedmedicine.com/2006/10/11/quiz-hair-on-end-skull/#comment-9000 JonMikel, M.D. Wed, 11 Oct 2006 18:56:16 +0000 http://www.unboundedmedicine.com/2006/10/11/quiz-hair-on-end-skull/#comment-9000 Excellent explanation and perfect answer!! Thank you for your kind comment. Excellent explanation and perfect answer!!

Thank you for your kind comment.

]]> By: Drmikeunoe http://www.unboundedmedicine.com/2006/10/11/quiz-hair-on-end-skull/#comment-8999 Drmikeunoe Wed, 11 Oct 2006 18:47:53 +0000 http://www.unboundedmedicine.com/2006/10/11/quiz-hair-on-end-skull/#comment-8999 We can see generalized osteopenia, widening of the diploetic space, and thinning of the outer table. This characteristic "hair on end" appearance of the outer table is compatible with the presence of massive hyperplasia of the bone marrow, as can be seen in the homozygous state of beta-thalassemia (i.e. thalassemia major). Beta thalassemia syndromes are a group of hereditary disorders characterized by a genetic deficiency in the synthesis of beta-globin chains (adult hemoglobin usually is α2β2) resulting in excess α-chains and severe transfusion-dependent anemia, thus causing bone marrow hyperplasia. We can see generalized osteopenia, widening of the diploetic space, and thinning of the outer table. This characteristic “hair on end” appearance of the outer table is compatible with the presence of massive hyperplasia of the bone marrow, as can be seen in the homozygous state of beta-thalassemia (i.e. thalassemia major). Beta thalassemia syndromes are a group of hereditary disorders characterized by a genetic deficiency in the synthesis of beta-globin chains (adult hemoglobin usually is α2β2) resulting in excess α-chains and severe transfusion-dependent anemia, thus causing bone marrow hyperplasia.

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